Ignite Creation Date:
2025-12-24 @ 7:35 PM
Ignite Modification Date:
2026-03-28 @ 12:03 PM
Study NCT ID:
NCT06347003
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2025-10-27
First Post:
2024-03-29
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Study of Plozasiran (ARO-APOC3) in Adults With Severe Hypertriglyceridemia
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D015228', 'term': 'Hypertriglyceridemia'}], 'ancestors': [{'id': 'D006949', 'term': 'Hyperlipidemias'}, {'id': 'D050171', 'term': 'Dyslipidemias'}, {'id': 'D052439', 'term': 'Lipid Metabolism Disorders'}, {'id': 'D008659', 'term': 'Metabolic Diseases'}, {'id': 'D009750', 'term': 'Nutritional and Metabolic Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C000731231', 'term': 'plozasiran'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 446}}, 'statusModule': {'overallStatus': 'ACTIVE_NOT_RECRUITING', 'startDateStruct': {'date': '2024-07-22', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-10', 'completionDateStruct': {'date': '2026-09', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-10-24', 'studyFirstSubmitDate': '2024-03-29', 'studyFirstSubmitQcDate': '2024-03-29', 'lastUpdatePostDateStruct': {'date': '2025-10-27', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2024-04-04', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-06', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Percent Change in Fasting Serum Triglyceride (TG) Levels from Baseline to Month 12 Compared to Placebo', 'timeFrame': 'Baseline, Month 12'}], 'secondaryOutcomes': [{'measure': 'Percent Change in Fasting Serum TG Levels from Baseline to Month 10 Compared to Placebo', 'timeFrame': 'Baseline, Month 10'}, {'measure': 'Proportion of Participants Who Achieve Fasting TG Levels of <500 mg/dL (<5.65 mmol/L) at Month 12 Compared to Placebo', 'timeFrame': 'Baseline, Month 12'}, {'measure': 'Proportion of Participants Who Achieve Fasting TG Levels of <150 mg/dL (<1.69 mmol/L) at Month 12 Compared to Placebo', 'timeFrame': 'Baseline, Month 12'}, {'measure': 'Percent change in remnant cholesterol (VLDL-C) from baseline to Month 12 compared to placebo', 'timeFrame': 'Baseline, Month 12'}, {'measure': 'Percent change in non-HDL-C from baseline to Month 12 compared to placebo', 'timeFrame': 'Baseline, Month 12'}, {'measure': 'Adjudicated AP Event Rate During the Treatment Period Compared to Placebo From Day 1 to Month 12', 'timeFrame': 'Month 12'}, {'measure': 'Number of participants with adverse events (AEs) and serious adverse events (SAEs) over time through Month 12 as compared to placebo', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Incidence Rates of New-Onset Diabetes Mellitus (NODM) Throughout the Course of Treatment', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Incidence rates of impaired glucose tolerance throughout the course of treatment', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Incidence rates of worsening of existing diabetes throughout the course of treatment', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Change from baseline in HbA1c during the treatment period compared to placebo.', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Change from Baseline in Fasting Blood Glucose During the Treatment Period Compared to Placebo', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Change from Baseline in C-peptide During the Treatment Period Compared to Placebo', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Change from Baseline in Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) During the Treatment Period Compared to Placebo', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Change from Baseline in Treatment-Emergent Adverse Events (TEAEs) and Treatment-Related Adverse Events (TRAEs) Associated with Worsening Glycemic Control During the Treatment Period Compared to Placebo', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Initiation of New Medication for Hyperglycemia Among Study Participants Not Known to Have Pre-existing Diabetes Mellitus During the Treatment Period Compared to Placebo', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Adjudicated Major Adverse Cardiovascular Events (MACE) Rates During the Treatment Period Compared to Placebo', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Incidence of Anti-drug Antibodies (ADA) to Plozasiran in Participants Receiving Plozasiran Over Time Through Month 12', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Titers of Anti-drug Antibodies (ADA) to Plozasiran in Participants Receiving Plozasiran Over Time Through Month 12', 'timeFrame': 'From first dose of study drug through Month 12'}, {'measure': 'Change and/or percent change from baseline to Month 12 in liver fat content using MRI-PDFF, only in a subset of subjects', 'timeFrame': 'Baseline, Month 12'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Severe Hypertriglyceridemia']}, 'descriptionModule': {'briefSummary': 'This Phase 3 study will evaluate the safety and efficacy of plozasiran injection (ARO-APOC3) in adult participants with severe hypertriglyceridemia (SHTG). After providing informed consent eligible participants will be randomized to receive 4 doses (once every 3 months) of plozasiran or placebo, and be evaluated for efficacy and safety. After month 12, eligible participants will be offered an opportunity to continue in an optional open-label extension under a separate protocol.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Males, or nonpregnant (who do not plan to become pregnant) nonlactating females, who are ≥18 years of age at screening\n* Established diagnosis of severe hypertriglyceridemia (SHTG) and prior documented evidence (medical history) of fasting TG levels of ≥ 500 mg/dL (≥5.65mmol/L)\n* Mean fasting TG level ≥500 mg/dL (≥5.65 mmol/L) collected at 2 separate and consecutive visits at least 7 days apart and no more than 17 days apart during the screening period\n* Fasting low density lipoprotein-cholesterol (LDL-C) ≤130 mg/dL (≤3.37 mmol/L) at screening\n* Screening HbA1C ≤9.0%\n* Willing to follow diet counseling and maintain a stable low-fat diet\n* Must be on standard of care lipid and TG lowering medications per local guidelines (unless documented as intolerant as determined by the Investigator, including an inability to safely administer or re-administer a specific drug because of fear, preference, genetic, clinical, or metabolic considerations, or due to a previous adverse reaction associated with, attributed to, or caused by specific drug)\n\nExclusion Criteria:\n\n* Use of any hepatocyte-targeted small interfering ribonucleic acid (siRNA) that targets lipids and/or triglycerides within 365 days before Day 1 (except inclisiran, which is permitted). Administration of investigational drug and inclisiran must be separated by at least 4 weeks\n* Use of any other hepatocyte-targeted siRNA or antisense oligonucleotide molecule within 60 days or within 5-half-lives before Day 1 based on plasma pharmacokinetics (PK), whichever is longer\n* Known diagnosis of familial chylomicronemia syndrome (FCS) (type 1 Hyperlipoproteinemia) by documentation of confirmed homozygote or double heterozygote for loss-of-function mutations in type 1-causing genes\n* Acute pancreatitis within 4 weeks prior to screening\n* Body mass index \\>45kg/m\\^2\n\nNote: Additional Inclusion/Exclusion criteria may apply per protocol'}, 'identificationModule': {'nctId': 'NCT06347003', 'acronym': 'SHASTA-3', 'briefTitle': 'Study of Plozasiran (ARO-APOC3) in Adults With Severe Hypertriglyceridemia', 'organization': {'class': 'INDUSTRY', 'fullName': 'Arrowhead Pharmaceuticals'}, 'officialTitle': 'Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Plozasiran in Adults With Severe Hypertriglyceridemia', 'orgStudyIdInfo': {'id': 'AROAPOC3-3003'}, 'secondaryIdInfos': [{'id': '2023-509300-14', 'type': 'EUDRACT_NUMBER'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Plozasiran Injection', 'description': '4 doses of plozasiran (ARO-APOC3) by subcutaneous (sc) injection', 'interventionNames': ['Drug: Plozasiran Injection']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo', 'description': 'calculated volume to match active treatment by sc injection', 'interventionNames': ['Drug: Placebo']}], 'interventions': [{'name': 'Plozasiran Injection', 'type': 'DRUG', 'otherNames': ['ARO-APOC3'], 'description': 'ARO-APOC3 Injection', 'armGroupLabels': ['Plozasiran Injection']}, {'name': 'Placebo', 'type': 'DRUG', 'description': 'sterile normal saline (0.9% NaCl)', 'armGroupLabels': ['Placebo']}]}, 'contactsLocationsModule': {'locations': [{'zip': '92844', 'city': 'Garden Grove', 'state': 'California', 'country': 'United States', 'facility': 'Research Center 1', 'geoPoint': {'lat': 33.77391, 'lon': -117.94145}}, {'zip': '92630', 'city': 'Lake Forest', 'state': 'California', 'country': 'United States', 'facility': 'Research Center 2', 'geoPoint': {'lat': 33.64697, 'lon': -117.68922}}, {'zip': '91763', 'city': 'Montclair', 'state': 'California', 'country': 'United States', 'facility': 'Research Center 3', 'geoPoint': {'lat': 34.07751, 'lon': -117.68978}}, {'zip': '91402', 'city': 'Panorama City', 'state': 'California', 'country': 'United States', 'facility': 'Research Center 4', 'geoPoint': {'lat': 34.22473, 'lon': -118.44981}}, {'zip': '96001', 'city': 'Redding', 'state': 'California', 'country': 'United States', 'facility': 'Research Center 5', 'geoPoint': {'lat': 40.58654, 'lon': -122.39168}}, {'zip': '80909', 'city': 'Colorado Springs', 'state': 'Colorado', 'country': 'United States', 'facility': 'Research Center 6', 'geoPoint': {'lat': 38.83388, 'lon': -104.82136}}, {'zip': '33016', 'city': 'Hialeah', 'state': 'Florida', 'country': 'United States', 'facility': 'Research Center 7', 'geoPoint': {'lat': 25.8576, 'lon': -80.27811}}, {'zip': '32055', 'city': 'Lake City', 'state': 'Florida', 'country': 'United States', 'facility': 'Research Center 8', 'geoPoint': {'lat': 30.18968, 'lon': -82.63929}}, {'zip': '33014', 'city': 'Miami Lakes', 'state': 'Florida', 'country': 'United States', 'facility': 'Research Center 9', 'geoPoint': {'lat': 25.90871, 'lon': -80.30866}}, {'zip': '32757', 'city': 'Mt. 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'country': 'United States', 'facility': 'Research Center 51', 'geoPoint': {'lat': 29.42412, 'lon': -98.49363}}, {'zip': '98109', 'city': 'Seattle', 'state': 'Washington', 'country': 'United States', 'facility': 'Research Center 52', 'geoPoint': {'lat': 47.60621, 'lon': -122.33207}}, {'zip': 'B1704ETD', 'city': 'Ramos Mejía', 'state': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Research Center 8', 'geoPoint': {'lat': -34.6551, 'lon': -58.55318}}, {'zip': '1642', 'city': 'San Isidro', 'state': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Research Center 10', 'geoPoint': {'lat': -34.46971, 'lon': -58.52111}}, {'zip': 'B1834GUK', 'city': 'Temperley', 'state': 'Buenos Aires', 'country': 'Argentina', 'facility': 'Research Center 7', 'geoPoint': {'lat': -34.77435, 'lon': -58.39347}}, {'zip': '5000', 'city': 'Córdoba', 'state': 'Córdoba Province', 'country': 'Argentina', 'facility': 'Research Center 4', 'geoPoint': {'lat': -31.40648, 'lon': -64.18853}}, {'zip': '5008', 'city': 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