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Compound Report Overview

Compound Name: RAPAMYCIN

Compound Identifier: 700739

Mol Structure 2D: 700739

Molecular Weight: 914

Formula: C51 H79 N O13

Development Status: US FDA Approved

SMILES: COC1CC(CC(C)C2CC(=O)C(C)C=C(C)C(O)C(OC)C(=O)C(C)CC(C)C=CC=CC=C(C)C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N4CCCCC4C(=O)O2)OC)CCC1O

Activities CAS Curations Identifiers Literature Properties Similarities SMILES Structures Synonyms Targets

Compound Literature

Compound	Gene Type	Activity	Description	View

RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	IC50	.0035	displaces, binding ([3H] FK506), enzyme expressed in Escherichia coli, purified by metal ion affinity chromatography, scintillation proximity assay (SPA)	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	IC50	.0035	displaces, binding ([3H] FK506), enzyme expressed in Escherichia coli, purified by metal ion affinity chromatography, scintillation proximity assay (SPA)	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	IC50	.0035	displaces, binding ([3H] FK506), enzyme expressed in Escherichia coli, purified by metal ion affinity chromatography, scintillation proximity assay (SPA)	View
RAPAMYCIN	IC50	.0035	displaces, binding ([3H] FK506), enzyme expressed in Escherichia coli, purified by metal ion affinity chromatography, scintillation proximity assay (SPA)	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	IC50	.0035	displaces, binding ([3H] FK506), enzyme expressed in Escherichia coli, purified by metal ion affinity chromatography, scintillation proximity assay (SPA)	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	IC50	.0035	displaces, binding ([3H] FK506), enzyme expressed in Escherichia coli, purified by metal ion affinity chromatography, scintillation proximity assay (SPA)	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	IC50	.0035	displaces, binding ([3H] FK506), enzyme expressed in Escherichia coli, purified by metal ion affinity chromatography, scintillation proximity assay (SPA)	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	IC50	.0035	displaces, binding ([3H] FK506), enzyme expressed in Escherichia coli, purified by metal ion affinity chromatography, scintillation proximity assay (SPA)	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	IC50	.0035	displaces, binding ([3H] FK506), enzyme expressed in Escherichia coli, purified by metal ion affinity chromatography, scintillation proximity assay (SPA)	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	IC50	.0035	displaces, binding ([3H] FK506), enzyme expressed in Escherichia coli, purified by metal ion affinity chromatography, scintillation proximity assay (SPA)	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	IC50	.0035	displaces, binding ([3H] FK506), enzyme expressed in Escherichia coli, purified by metal ion affinity chromatography, scintillation proximity assay (SPA)	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	Eff Conc	10	inhibits, enzyme activity as an immunophilin (FKBP12) complex, rat brain derived mTOR	View
RAPAMYCIN	IC50	.0035	displaces, binding ([3H] FK506), enzyme expressed in Escherichia coli, purified by metal ion affinity chromatography, scintillation proximity assay (SPA)	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	IC50	.0035	displaces, binding ([3H] FK506), enzyme expressed in Escherichia coli, purified by metal ion affinity chromatography, scintillation proximity assay (SPA)	View
RAPAMYCIN	IC50	.0035	displaces, binding ([3H] FK506), enzyme expressed in Escherichia coli, purified by metal ion affinity chromatography, scintillation proximity assay (SPA)	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View
RAPAMYCIN	IC50	.0035	displaces, binding ([3H] FK506), enzyme expressed in Escherichia coli, purified by metal ion affinity chromatography, scintillation proximity assay (SPA)	View
RAPAMYCIN	IC50	1	increases, binding([3H]saxitoxin), bovine adrenal chromaffin cells, reflective of up-regulation of cell surface sodium channels	View
RAPAMYCIN	Eff Conc	.00109	inhibits, expression (TNF- related apaptosis inducing ligand), murine T cells	View