Gene:
kalirin, RhoGEF kinase
Gene ID:
197922
Symbol:
KALRN
Species:
1000
Description:
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. An alternatively spliced variant has been described but its full-length sequence has not been determined.