Gene:
mitogen-activated protein kinase 8 interacting protein 2
Gene ID:
193818
Symbol:
MAPK8IP2
Species:
1000
Description:
The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.