Gene:
hematopoietic SH2 domain containing
Gene ID:
198519
Symbol:
HSH2D
Species:
1000
Description:
T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003).[supplied by OMIM]