Gene:
ER degradation enhancer, mannosidase alpha-like 1
Gene ID:
198833
Symbol:
EDEM1
Species:
1000
Description:
Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. It lacks mannosidase activity.