Gene:
aldehyde dehydrogenase 1 family, member A3
Gene ID:
199474
Symbol:
ALDH1A3
Species:
1000
Description:
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene for this human isozyme spans about 37 kb and consists of 13 exons. It is expressed at low levels in many tissues and at higher levels in salivary gland, stomach and kidney. The major transcript is approximately 3.5 kb; however, there is a less abundant transcript that is smaller by 111 bp in the 3' non-coding region and uses an alternative polyadenylation signal. The significance of alternative splicing of this gene is currently unclear.