Gene:
caspase 10, apoptosis-related cysteine protease
Gene ID:
199721
Symbol:
CASP10
Species:
1000
Description:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein was shown to cleave and activate caspases 3 and 7, and itself could be processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Four alternatively spliced transcript variants encoding different isoforms have been described for this gene.