Gene:
host cell factor C1 (VP16-accessory protein)
Gene ID:
200341
Symbol:
HCFC1
Species:
1000
Description:
Involved in control of the cell cycle. Upon lytic infection of permissive cells, the HSV transactivator protein VP16 associates with HCFC1. Binding to HCFC1 activates VP16 for association with the octamer motif-binding protein POU2F1, to form a multiprotein-DNA complex responsible for activating transcription of the HSV immediate early genes. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3-K4 methyltrasferase (HMT) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together.