Gene:
SEC3-like 1 (S. cerevisiae)
Gene ID:
201709
Symbol:
SEC3L1
Species:
1000
Description:
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the v-ral simian leukemia viral oncogene homolog A (RALA). RALA is a Ras-related small GTPase involved in controlling actin cytoskeletal remodeling and vesicle transport, which therefore suggests that the exocyst may act as an effector for activated RALA in directing site of exocytosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.