Gene:
poly (ADP-ribose) polymerase family, member 4
Gene ID:
202442
Symbol:
PARP4
Species:
1000
Description:
This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.