Gene:
clathrin, light polypeptide (Lca)
Gene ID:
202456
Symbol:
CLTA
Species:
1000
Description:
Clathrin is the main structural component of the lattice covering the cytoplasmic face of the coated pits and coated vesicles in which specific macromolecules are entrapped in the process of receptor-mediated endocytosis. Clathrin is a large, soluble protein composed of heavy chains and light chains. Two genes, CLTA and CLTB encode the clathrin light chain proteins. The light chains are believed to be regulatory elements in clathrin function. The brain-specific light chain variant contains an insert ecoding 30 amino acids immediately downstream of the region encoding the heavy chain binding domain.