Gene:
dihydrofolate reductase
Gene ID:
202608
Symbol:
DHFR
Species:
1000
Description:
Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, four intronless processed pseudogenes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia.