Gene:
transcription factor 7-like 1 (T-cell specific, HMG-box)
Gene ID:
202811
Symbol:
TCF7L1
Species:
1000
Description:
Participates in the Wnt signaling pathway. Binds to DNA and acts as repressor in the absence of CTNNB1, and as activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.