Gene:
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
Gene ID:
202851
Symbol:
CD47
Species:
1000
Description:
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.