Gene:
hypoxia-inducible factor 1, alpha subunit inhibitor
Gene ID:
202878
Symbol:
HIF1AN
Species:
1000
Description:
Hydroxylates HIF-1 alpha at Asp-803 in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases.