Gene:
poliovirus receptor-related 2 (herpesvirus entry mediator B)
Gene ID:
192114
Symbol:
PVRL2
Species:
1000
Description:
CD112 is an adhesion molecule widely expressed in cell lines of different lineages, including hematopoietic, neuronal, endothelial and epithelial cells. In 1995, CD112 was identified and reported in humans. Later it was identified as a transmembrane molecule related to CD155 and named Poliovirus Receptor Related2 (PRR2). CD112 belongs to a new family of immunoglobulin-like molecules that includes four members (CD111 , CD112, PRR3 and CD155) sharing an ectodomain made of three Ig domains, of V, C, C types. CD112 encodes for 2 different transmembrane isoforms sharing identical ectodomain but different transmembrane and cytoplasmic regions. CD112 is expressed in the myelo-monocytic and megakaryocytic hematopoietic lineages and the function in hematopoiesis is currently unknown. CD112 is an intercellular homophilic adhesion. Homophilic adhesion correlates with the tyrosine phosphorylation of the long isoform. CD112 localizes specifically at adherens junctions via its cytoplasmic interaction with the scaffold F-actin binding protein afadin. This interaction is mediated by a sequence located to the C terminal ends of both isoforms of CD112 (A/ExYV) and the PDZ domain of afadin. Disruption of the murine CD112 gene leads to infertility of male mice with morphologically aberrant spermatozoa. CD112 mediates entry of some alphaherpesvirus mutants (also named HveB) via its V domain. CD112 is involved in cell to cell spreading of the virus.