Gene:
ubiquitin A-52 residue ribosomal protein fusion product 1
Gene ID:
203258
Symbol:
UBA52
Species:
1000
Description:
Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and the 52-amino acid ribosomal protein L40. Ribosomal protein L40 is a component of the 60S subunit of the ribosome and belongs to the L40E family of ribosomal proteins. It contains a zinc finger-like domain and is located in the cytoplasm. Multiple processed pseudogenes derived from this gene are present in the genome. As with ribosomal protein L40, ribosomal protein S27a is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi.