Gene:
integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
Gene ID:
203413
Symbol:
ITGAE
Species:
1000
Description:
ITGAE encodes integrin alpha chain E. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin undergoes post-translational cleavage in the extracellular domain that yields disulfide-linked heavy and light chains, In combination with beta 7 (ITGB7) these chains form the E-cadherin binding integrin known as 'human mucosal lymphocyte-1' antigen (HML-1). This integrin is preferentially expressed on human intestinal intraepithelial lymphocytes (IEL), and in addition to adhesion, it may serve as an accessory molecule for IEL activation.