Gene:
TNF receptor-associated factor 5
Gene ID:
203597
Symbol:
TRAF5
Species:
1000
Description:
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein has been found to be one of the components of a multiple protein complex associated with the CD40 cytoplasmic domain, which mediates TNF induced NF-kappa B activation and protection from cell death. This protein has also been implicated in the signaling events mediated by various other receptors including CD27, CD30, and lymphotoxin-beta receptor. Two alternatively spliced transcript variants encoding the same protein have been reported.