Gene:
O-6-methylguanine-DNA methyltransferase
Gene ID:
209162
Symbol:
MGMT
Species:
1000
Description:
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.