Gene:
low density lipoprotein receptor-related protein 6
Gene ID:
209081
Symbol:
LRP6
Species:
1000
Description:
Essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. Specific high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.