Gene:
PH domain and leucine rich repeat protein phosphatase
Gene ID:
208767
Symbol:
PHLPP
Species:
1000
Description:
Protein phosphatase that specifically mediates dephosphorylation of Ser-473 of AKT1, a protein that regulate the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of Ser- 473 of AKT1 triggers apoptosis and suppression of tumor growth. May act as a negative regulator of K-Ras signaling in the membrane rafts.