Gene:
protein inhibitor of activated STAT, 4
Gene ID:
208342
Symbol:
PIAS4
Species:
1000
Description:
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway, the wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing.