Gene:
proteinase 3 (serine proteinase, neutrophil, Wegener granulomatosis autoantigen)
Description:
Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.