Gene:
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
Gene ID:
207950
Symbol:
MSH2
Species:
1000
Description:
MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC.