Gene:
distal-less homeo box 6
Description:
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. DLX5 and DLX6 are closely linked in an inverted convergent (tail-to-tail) configuration. The DLX proteins are postulated to play a role in forebrain and craniofacial development.