Gene:
pancreatic polypeptide
Gene ID:
191111
Symbol:
PPY
Species:
1000
Description:
Pancreatic polypeptide (PPY) was the first identified product of the dominating endocrine cell type of the duodenal pancreas (Kimmel et al., 1975; Larsson et al., 1976). This hormone of 36 amino acids seems to be involved in the regulation of exocrine pancreatic secretion and biliary tract motility (Schwartz, 1983). PPY may be important in regulation of food intake; genetically obese laboratory animals have altered PPY release and in New Zealand obese mice weight gain can be cured by infusion of PPY. Children with Prader-Willi syndrome (PWS; MIM 176270) have blunted secretion of PPY (Zipf et al., 1981).[supplied by OMIM]