Gene:
interferon, alpha-inducible protein (clone IFI-15K)
Gene ID:
191205
Symbol:
G1P2
Species:
1000
Description:
Acts as ubiquitin by conjugation to intracellular target proteins, through an enzyme pathway distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. Targets include SERPINA3G/SPI2A, JAK1, MAPK3/ERK1 and PLCG1. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages.