Gene:
KH domain containing, RNA binding, signal transduction associated 1
Gene ID:
191931
Symbol:
KHDRBS1
Species:
1000
Description:
Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Isoform 3 is only expressed in growth-arrested cells and inhibits S phase entry.