Gene:
ubiquitin-like, containing PHD and RING finger domains, 1
Gene ID:
191034
Symbol:
UHRF1
Species:
1000
Description:
UHRF1 binds to an inverted CCAAT box in the promoter of topoisomerase II-alpha (TOP2A; MIM 126430). TOP2A introduces transient double-stranded breaks in DNA, which are required during the cell cycle for DNA replication, chromosome condensation, and segregation. UHRF1 is likely involved in TOPO2A expression (Hopfner et al., 2000).[supplied by OMIM]