Gene:
thioredoxin reductase 2
Gene ID:
204988
Symbol:
TXNRD2
Species:
1000
Description:
Thioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. TR is a member of a family of pyridine nucleotide-disulfide oxidoreductases and is a key enzyme in the regulation of the intracellular redox environment. Three thioredoxin reductase genes have been found that encode selenocysteine containing proteins. Alternative splicing of this gene results in three distinct transcripts encoding different isoforms, one of which has been shown to be located in the mitochondria. This TR gene partially overlaps the COMT gene on chromosome 22.