Gene:
PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
Gene ID:
194325
Symbol:
PMS2
Species:
1000
Description:
This gene is one of the PMS2 gene family members which are found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. The protein forms a heterodimer with MLH1 and this complex interacts with MSH2 bound to mismatched bases. Defects in this gene are associated with hereditary nonpolyposis colorectal cancer, with a Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants encoding different isoforms have been identified.