Gene:
transmembrane protease, serine 11D
Gene ID:
193099
Symbol:
TMPRSS11D
Species:
1000
Description:
Human airway trypsin-like protease (HAT) is a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region had little similarity to other known proteins. HAT may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.