Gene:
ubiquitin-conjugating enzyme E2S
Description:
The protein encoded by this gene is a family member of enzymes known as ubiquitin carrier proteins, or E2s, which are an essential component of the ubiquitin-protein conjugation system. This protein exhibits E2 enzyme activity in its ability to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme (E1)-dependent manner. This protein is the first member of this E2 family to be cloned from an epidermal source.