Gene:
a disintegrin and metalloproteinase domain 12 (meltrin alpha)
Gene ID:
190956
Symbol:
ADAM12
Species:
1000
Description:
This gene encodes a disintegrin and metalloprotease (ADAM) domain 12, which is a member of the ADAM protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene has 2 alternative splicing transcript forms: a shorter secreted form and a longer membrane-bound form, that diverge at their 3' ends. The shorter form is found to stimulate myogenesis.