Gene:
SEC5-like 1 (S. cerevisiae)
Gene ID:
190993
Symbol:
SEC5L1
Species:
1000
Description:
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the v-ral simian leukemia viral oncogene homolog A (RALA), a Ras-related small GTPase involved in controlling actin cytoskeletal remodeling and vesicle transport. The binding of this protein to RALA has been shown to mediate filopodia formation in fibroblasts. Mutation studies of the similar gene in Drosophila suggested that this protein is required for neuronal membrane traffic.