Gene:
prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy)
Gene ID:
205891
Symbol:
PSAP
Species:
1000
Description:
Prosaposin is a 511-amino acid glycoprotein which is a precursor for 4 saposins that are designated A, B, C, and D (Morimoto et al., 1989). Each domain of the precursor protein is approximately 80 amino acid residues long; has nearly identical placement of cysteine residues, glycosylation sites, and helicoregions; and is flanked by proteolytic cleavage sites. Proteolytic cleavage of prosaposin at each domain boundary is predicted to give rise to 4 saposin proteins. The PSAP gene can be said to be polycistronic.[supplied by OMIM]