Gene:
eukaryotic translation initiation factor 2-alpha kinase 3
Gene ID:
194532
Symbol:
EIF2AK3
Species:
1000
Description:
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1 (By similarity).