Gene:
solute carrier family 1 (glial high affinity glutamate transporter), member 2
Gene ID:
195520
Symbol:
SLC1A2
Species:
1000
Description:
Glutamate transporters are membrane-bound proteins localized in glial cells and/or presynaptic glutamatergic nerve endings. They are essential for the removal and termination of action of the excitatory neurotransmitter glutamate from the synapse (Shashidharan et al., 1994). Several subtypes of glutamate transporters have been defined by differences in sequence, pharmacology, tissue distribution, and channel-like properties, including SLC1A2 (EAAT2), SLC1A3 (EAAT1 or GLAST; MIM 600111), SLC1A1 (EAAC1 or EAAT3; MIM 133550), and SLC1A6 (EAAT4; MIM 600637). SLC1A2 is selectively localized to astroglia; SLC1A1 and SLC1A6 are selectively localized in neurons; and SLC1A3 is found in both neurons and astroglia (Rothstein et al., 1994; Maragakis et al., 2004).[supplied by OMIM]