Gene:
spectrin, beta, non-erythrocytic 1
Gene ID:
195625
Symbol:
SPTBN1
Species:
1000
Description:
Spectrin is a tetrameric cytoskeletal protein essential for determination of cell shape, resilience of membranes to mechanical stress, positioning of transmembrane proteins, and organization of organelles and molecular traffic. Alpha- and beta-spectrin subunits form antiparallel dimers that self associate to give the spectrin tetramer. Beta subunits, such as SPTBN1, contain most of the spectrin binding activity (Hayes et al., 2000).[supplied by OMIM]