Gene:
clathrin, light polypeptide (Lcb)
Gene ID:
195630
Symbol:
CLTB
Species:
1000
Description:
Clathrin is the main structural component of the lattice covering the cytoplasmic face of the coated pits and coated vesicles in which specific macromolecules are entrapped in the process of receptor-mediated endocytosis. Clathrin is a large, soluble protein composed of heavy chains and light chains. Two genes encode the clathrin light chain proteins. The light chains are believed to be regulatory elements in clathrin function. The brain-specific light chain variant contains an insert encoding 18 aa immediately downstream of the region encoding the heavy chain binding domain. Two transcript variants encoding different isoforms have been found for this gene.