Gene:
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
Gene ID:
195656
Symbol:
TLE1
Species:
1000
Description:
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.