Gene:
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
Gene ID:
196098
Symbol:
IKBKAP
Species:
1000
Description:
The protein encoded by this gene is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. This encoded protein can bind NF-kappa-B-inducing kinase (NIK) and IKKs through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia.