Gene:
hepatocyte nuclear factor 4, alpha
Gene ID:
196311
Symbol:
HNF4A
Species:
1000
Description:
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. At least three different transcript variants encoding three different isoforms have been found for this gene.