Gene:
tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory)
Gene ID:
196743
Symbol:
TIMP3
Species:
1000
Description:
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The expression of this gene is induced in response to mitogenic stimulation and subject to cell cycle regulation. Mutations in this gene cause the autosomal dominant disorder Sorsby's fundus dystrophy.