Gene:
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1
Gene ID:
197384
Symbol:
ADAMTS1
Species:
1000
Description:
This gene encodes a disintegrin and metalloproteinase with thrombospondin motifs-1 (ADAMTS1), which is a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains 2 disintegrin loops and 3 C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.