| - |
- |
|
|
-
|
View
|
| - |
- |
|
|
Involved in endocytosis (By similarity).
|
View
|
| TNS4 |
- |
|
|
-
|
View
|
| - |
- |
|
|
-
|
View
|
| SBNO1 |
- |
|
|
-
|
View
|
| Crh |
- |
|
|
binds CRH receptors and mediates neuroendocrine stress response; may play a role in the consolidation of long term memory [RGD]
|
View
|
| Map2k6 |
- |
|
|
activator of p38 MAPK; may play a role in cardiac hypertrophic and failure conditions [RGD]
|
View
|
| VGCNL1 |
- |
|
|
-
|
View
|
| C13orf11 |
- |
|
|
-
|
View
|
| - |
- |
|
|
-
|
View
|
| Galr3 |
- |
|
|
binds galanin; mediates activation of GIRK1 and GIRK4 channel inward K+ currents; may play a role in neurotransmitter release [RGD]
|
View
|
| Gabre |
- |
|
|
subunit that may modify GABA-A receptor activity to confer benzodiazepine insensitivity [RGD]
|
View
|
| Gmfb |
- |
|
|
transcription factor; may be important for brain cell development [RGD]
|
View
|
| - |
- |
|
|
-
|
View
|
| SDHAL2 |
- |
|
|
-
|
View
|
| RASL11B |
- |
|
|
-
|
View
|
| - |
- |
|
|
-
|
View
|
| POLE2 |
- |
|
|
Participates in DNA repair and in chromosomal DNA replication.
|
View
|
| Gria3 |
- |
|
|
glutamate responsive ion channel subunit; has AMPA receptor activity that is enhanced by 2-pyrrolidinone [RGD]
|
View
|
| Fut2 |
- |
|
|
catalyzes the conversion of GDP-L-fucose and beta-D-galactosyl-R to GDP and alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R [RGD]
|
View
|
| - |
- |
|
|
-
|
View
|
| Gas6 |
- |
|
|
provides protection of neurons against serum deprivation-induced apoptosis [RGD]
|
View
|
| TSCOT |
- |
|
|
May act as a transporter (By similarity).
|
View
|
| ECM1 |
- |
|
|
This gene encodes an extracellular protein containing motifs with a cysteine pattern characteristic of the cysteine pattern of the ligand-binding …
|
View
|
| KIAA1033 |
- |
|
|
-
|
View
|
| LSS |
- |
|
|
The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member …
|
View
|
| - |
- |
|
|
-
|
View
|
| ITPR2 |
- |
|
|
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
|
View
|
| NLE1 |
- |
|
|
-
|
View
|
| CCNJ |
- |
|
|
-
|
View
|
| DOCK7 |
- |
|
|
Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Does …
|
View
|
| - |
- |
|
|
-
|
View
|
| CPNE2 |
- |
|
|
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one …
|
View
|
| ATP6V1G2 |
- |
|
|
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase …
|
View
|
| ITGAV |
- |
|
|
ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta …
|
View
|
| RNUXA |
- |
|
|
-
|
View
|
| PTK6 |
- |
|
|
The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer …
|
View
|
| C9orf64 |
- |
|
|
-
|
View
|
| RBM33 |
- |
|
|
-
|
View
|
| - |
- |
|
|
-
|
View
|
| - |
- |
|
|
-
|
View
|
| Csnk1g1 |
- |
|
|
This probe is non-specific and may hybridize to multiple genes. GeneID:144010/casein kinase 1, gamma 1; GeneID:170970/ESTs
|
View
|
| Cdc20 |
- |
|
|
may play a role in cell cycle regulated protein degradation [RGD]
|
View
|
| Cdc25a |
- |
|
|
novel phosphatase that mediates the start of the cell cycle; predominantly expressed in late G1, does not fucntion as mitotic …
|
View
|
| Cirbp |
- |
|
|
expression decreased by ischemia and H2O2; may mediate generation of reactive oxygen species [RGD]
|
View
|
| Cplx1 |
- |
|
|
binds the assembled SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) complex; modulates synaptic vesicle exocytosis [RGD]
|
View
|
| Coro1a |
- |
|
|
actin binding protein; may be phosphorylated by PKC [RGD]
|
View
|
| - |
- |
|
|
-
|
View
|
| KDELR3 |
- |
|
|
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal …
|
View
|
| Mycs |
- |
|
|
high expression is involved in tumor growth suppression in nude mice [RGD]
|
View
|
| Myh6 |
- |
|
|
heavy chain of myosin; involved in muscle contraction [RGD]
|
View
|
| Myh13 |
- |
|
|
member of the muscle myosin heavy chain (MHC) isoform family important in facilitating extraocular muscle contraction; may indirectly enable saccades …
|
View
|
| Nrxn2 |
- |
|
|
neuronal cell recognition molecule; may have a role in synaptogenesis [RGD]
|
View
|
| Mmp8 |
- |
|
|
may play a role in appositional bone formation and regulation of the extracellular matrix [RGD]
|
View
|
| Notch2 |
- |
|
|
transmembrane protein that may be involved in cellular interactions that specify cell fate [RGD]
|
View
|
| Il4i1_predicted |
- |
|
|
component of the nuclear pore complex; may be involved in nuclear pore transport [RGD]
|
View
|
| Nr5a1 |
- |
|
|
transcription factor; essential for adrenal and gonadal development [RGD]
|
View
|
| Nucb1 |
- |
|
|
extracellular calcium binding protein of the mineralized matrix of bone [RGD]
|
View
|
| Fgf5 |
- |
|
|
member of the fibroblast growth factor (FGF) family; implicated in activities including embryonic development, cell growth, morphogenesis, tissue growth, and …
|
View
|
| GPR62 |
- |
|
|
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM]
|
View
|
| Flot2 |
- |
|
|
colocalized with activated GPI-linked cell adhesion molecules at the plasma membrane where transmembrane signaling may occur [RGD]
|
View
|
| Stag3 |
- |
|
|
testis-specific protein which associates with the synaptonemal complex [RGD]
|
View
|
| Galr2 |
- |
|
|
mediates inositol phospholipid turnover and intracellular calcium levels; functions through the activation of phospholipase C [RGD]
|
View
|
| - |
- |
|
|
-
|
View
|
| Gdf8 |
- |
|
|
positive regulator of satellite cell function in skeletal muscle; overexpression may inhibit satellite cell proliferation and thus contribute to skeletal …
|
View
|
| - |
- |
|
|
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the …
|
View
|
| Pter |
- |
|
|
binds resiniferatoxin, which desensitises nociceptive neurons; may play a role in resiniferatoxin toxicity [RGD]
|
View
|
| Kcnk15 |
- |
|
|
TWIK-related acid-sensitive potassium channel; involved in setting the resting potential of neurons [RGD]
|
View
|
| Kcnj9 |
- |
|
|
G-protein activated potassium channel [RGD]
|
View
|
| Kcna6 |
- |
|
|
voltage-gated potassium channel [RGD]
|
View
|
| Kcnq1 |
- |
|
|
pore-forming subunit of potassium channels; mutations in human homolog are associated with both Romano-Ward syndrome and Jervell and Lange-Nielsen syndrome …
|
View
|
| Porf1 |
- |
|
|
may play a role in the peripubertal process during development of the neuroendocrine axis [RGD]
|
View
|
| Pip |
- |
|
|
secretory protein localized to acinar cells of neonatal and adult submandibular and parotid glands, also expressed in sublingual glands [RGD]
|
View
|
| ACD |
- |
|
|
-
|
View
|
| Shank2 |
- |
|
|
binds to cortactin and alpha-latrotoxin receptor and is involved in the structural and functional organization of the post synaptic density …
|
View
|
| Pcsk4 |
- |
|
|
member of the Kex2/subtilisin-like proprotein convertases; may mediate the developmental maturation of germ cells [RGD]
|
View
|
| SFN |
- |
|
|
p53-regulated inhibitor of G2/M progression.
|
View
|
| NIPA1 |
- |
|
|
This gene encodes a potential transmembrane protein which may function as a receptor or transporter molecule. This protein may play …
|
View
|
| C6orf148 |
- |
|
|
-
|
View
|
| ZNF313 |
- |
|
|
May play a role in spermatogenesis.
|
View
|
| SLC7A2 |
- |
|
|
Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine).
|
View
|
| CCNL1 |
- |
|
|
-
|
View
|
| TPP1 |
- |
|
|
Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown …
|
View
|
| FTS |
- |
|
|
The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die …
|
View
|
| CXorf20 |
- |
|
|
-
|
View
|
| SLC22A17 |
- |
|
|
-
|
View
|
| C15orf12 |
- |
|
|
This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts with …
|
View
|
| TBX19 |
- |
|
|
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. …
|
View
|
| C21orf34 |
- |
|
|
-
|
View
|
| CXCR6 |
- |
|
|
Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.
|
View
|
| DGCR12 |
- |
|
|
Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal …
|
View
|
| KATNAL1 |
- |
|
|
Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays (By similarity).
|
View
|
| NR1H3 |
- |
|
|
Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding …
|
View
|
| - |
- |
|
|
-
|
View
|
| DHRS3 |
- |
|
|
Catalyzes the reduction of all-trans-retinal to all- trans-retinol in the presence of NADPH.
|
View
|
| - |
- |
|
|
-
|
View
|
| - |
- |
|
|
-
|
View
|
| KIAA1117 |
- |
|
|
-
|
View
|
| KIAA1958 |
- |
|
|
-
|
View
|
| PRTFDC1 |
- |
|
|
-
|
View
|
| TSNAX |
- |
|
|
This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions …
|
View
|
| - |
- |
|
|
-
|
View
|
| TCF4 |
- |
|
|
TCF4 encodes transcription factor 4, a basic helix-turn-helix transcription factor. The protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - …
|
View
|
| - |
- |
|
|
-
|
View
|
| - |
- |
|
|
-
|
View
|
| C19orf2 |
- |
|
|
The protein encoded by this gene binds to RNA polymerase II subunit 5 (RPB5) and negatively modulates transcription through its …
|
View
|
| - |
- |
|
|
-
|
View
|
| - |
- |
|
|
-
|
View
|
| CRADD |
- |
|
|
The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. …
|
View
|
| TCEA3 |
- |
|
|
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property …
|
View
|
| ST8SIA5 |
- |
|
|
The protein encoded by this gene is a type II membrane protein that may be present in the Golgi apparatus. …
|
View
|
| C18orf15 |
- |
|
|
-
|
View
|
| TRIM15 |
- |
|
|
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three …
|
View
|
| BMF |
- |
|
|
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and …
|
View
|
| BRCA1 |
- |
|
|
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. …
|
View
|
| LMOD3 |
- |
|
|
-
|
View
|
| PRKRA |
- |
|
|
-
|
View
|
| DNAJA1 |
- |
|
|
Co-chaperone of Hsc70. Seems to play a role in protein import into mitochondria.
|
View
|
| SPIC |
- |
|
|
Probable transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer.
|
View
|
| - |
- |
|
|
-
|
View
|
| PDK4 |
- |
|
|
Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose …
|
View
|
| ZBTB7B |
- |
|
|
ZFP67 is an early growth response gene that encodes a zinc finger-containing transcription factor that binds to the promoter regions …
|
View
|
| ZNF91 |
- |
|
|
-
|
View
|
| - |
- |
|
|
-
|
View
|
| - |
- |
|
|
-
|
View
|
| - |
- |
|
|
-
|
View
|
| - |
- |
|
|
-
|
View
|
| CHRAC1 |
- |
|
|
CHRAC1 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold …
|
View
|
| BFAR |
- |
|
|
-
|
View
|
| KIR2DS1 |
- |
|
|
Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
|
View
|
| C13orf25 |
- |
|
|
-
|
View
|
| PZP |
- |
|
|
Is able to inhibit all four classes of proteinases by a unique trapping mechanism. This protein has a peptide stretch, …
|
View
|
| LY6K |
- |
|
|
-
|
View
|
| DLX2 |
- |
|
|
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members …
|
View
|
| MSH6 |
- |
|
|
-
|
View
|
| XRN1 |
- |
|
|
SEP1 localizes to cytoplasmic foci containing a complex of mRNA-degrading enzymes. In addition to mRNA metabolism, yeast Sep1 has been …
|
View
|
| - |
- |
|
|
-
|
View
|
| - |
- |
|
|
-
|
View
|
| LRRC4B |
- |
|
|
-
|
View
|
| ZNF670 |
- |
|
|
-
|
View
|
| HTR2A |
- |
|
|
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, …
|
View
|
| UGCGL2 |
- |
|
|
Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control …
|
View
|
| PIGL |
- |
|
|
This gene encodes an enzyme that catalyzes the second step of glycosylphosphatidylinositol (GPI) biosynthesis, which is the de-N-acetylation of N-acetylglucosaminylphosphatidylinositol …
|
View
|
| CEP1 |
- |
|
|
This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product …
|
View
|
| HPS1 |
- |
|
|
This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and …
|
View
|
| LMAN2L |
- |
|
|
May function as a regulator of ERGIC-53.
|
View
|
| ATP6V0A4 |
- |
|
|
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase …
|
View
|
| - |
- |
|
|
Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'- phosphopantotheine.
|
View
|
| SALL2 |
- |
|
|
Probable transcription factor.
|
View
|
| P2RX2 |
- |
|
|
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion …
|
View
|
| - |
- |
|
|
May be involved in inhibiting testis spermatogenesis apoptosis.
|
View
|
| C9orf44 |
- |
|
|
-
|
View
|
| HMGB2 |
- |
|
|
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are …
|
View
|
| THOP1 |
- |
|
|
Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade …
|
View
|
| - |
- |
|
|
-
|
View
|
| - |
- |
|
|
-
|
View
|
| MADCAM1 |
- |
|
|
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin …
|
View
|
| TIAF1 |
- |
|
|
May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity).
|
View
|
| MMP19 |
- |
|
|
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such …
|
View
|
| HYOU1 |
- |
|
|
The protein encoded by this gene belongs to the heat shock protein 70 family. This gene has three mRNAs from …
|
View
|
| DDX49 |
- |
|
|
-
|
View
|
| WDR56 |
- |
|
|
-
|
View
|
| RPA1 |
- |
|
|
-
|
View
|
| PTPRC |
- |
|
|
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to …
|
View
|
| RARS |
- |
|
|
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino …
|
View
|
| POLE |
- |
|
|
-
|
View
|
| KRTAP4-15 |
- |
|
|
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), …
|
View
|
| ZNF169 |
- |
|
|
May be involved in transcriptional regulation.
|
View
|
| CREB5 |
- |
|
|
The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger …
|
View
|
| - |
- |
|
|
-
|
View
|
| HOXB2 |
- |
|
|
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors …
|
View
|
| CD2 |
- |
|
|
CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T cells and other cell types. CD2 …
|
View
|
| CSF2RB |
- |
|
|
CSF2RB is a common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defective CSF2RB has been …
|
View
|
| - |
- |
|
|
Translokin binds basic fibroblast growth factor (FGF2; MIM 134920) and mediates its nuclear translocation and mitogenic activity (Bossard et al., …
|
View
|
| - |
- |
|
|
-
|
View
|
| MRGPRF |
- |
|
|
Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of …
|
View
|
| ULBP1 |
- |
|
|
Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK …
|
View
|
| - |
- |
|
|
-
|
View
|
| PDPK1 |
- |
|
|
TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other transmembrane domain, called fusion peptide, …
|
View
|
| KCNA10 |
- |
|
|
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions …
|
View
|
| FBXO17 |
- |
|
|
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, …
|
View
|
| COIL |
- |
|
|
The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are …
|
View
|
| SATL1 |
- |
|
|
-
|
View
|
| - |
- |
|
|
The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It …
|
View
|
| KCNH5 |
- |
|
|
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their …
|
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| GPR123 |
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Orphan receptor.
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| NDUFA7 |
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Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be …
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| MRPL14 |
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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) …
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| NRXN3 |
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Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They …
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| RGL2 |
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Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and …
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| KBTBD5 |
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-
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| DBP |
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DBP is a member of the PAR bZIP (proline and acidic amino acid-rich basic leucine zipper) transcription factor family (Khatib …
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| - |
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| HOXB9 |
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This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors …
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| GRK1 |
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This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase …
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| - |
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| ASB7 |
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The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein …
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