Gene Data From HGNC: https://www.genenames.org/download/statistics-and-files/
Symbol:
FGB
Name:
fibrinogen beta chain
Location:
04q31.3
Locus Group:
protein-coding gene
Gene Type:
Protein Coding
Locus Type:
gene with protein product
DrugMatrix Data: https://cebs.niehs.nih.gov/cebs/paper/15670
DrugMatrix Gene Data For: 1 Matched Gene
Gene Name: fibrinogen, B beta polypeptide
Symbol:
Description: The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. S1 mapping studies on the 5'-flanking region of this gene revealed three transcription initiation points. Transcript variants utilizing alternative polyA signals have been described in the literature.
