Viewing Gene With DrugMatrix Data

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Gene Data From HGNC: https://www.genenames.org/download/statistics-and-files/
Symbol: DIO3
Name: iodothyronine deiodinase 3
Location: 14q32.31
Locus Group: protein-coding gene
Gene Type: Protein Coding
Locus Type: gene with protein product
ID+ Clinical Trials CompTox DrugMatrix Conditions Design Enrollment Locations Outcomes
DrugMatrix Data: https://cebs.niehs.nih.gov/cebs/paper/15670
Gene | Activity | Annotation | GO | Identifier | Pathway | Signature | Simple | Tissue
Target | Accession | Expression | Synonym | Pathway Gene | Gene Platform | Pathway Target
DrugMatrix Gene Data For: 1 Matched Gene
Gene Name: deiodinase, iodothyronine, type III
Symbol:
View DrugMatrix Gene Data
Species: 1000
Description: Type III iodothyronine deiodinase, a selenoprotein, is an important enzyme for thyroid hormone inactivation. It catalyzes the inner ring deiodination of the prohormone thyroxine (T4) and of the bioactive hormone 3,3',5-triiodothyronine (T3) to 3,3'-T2 to inactive metabolites. Selenocysteine, at aa position 144, is essential for efficient enzyme activity. The expression of this enzyme in placenta and several fetal tissues during early development, suggests that it plays a role in the regulation of thyroid hormone inactivation during embryologic development.